abstract：BACKGROUND AND AIMS:There is increasing awareness that the intestinal microbiome plays an important role in human health. We investigated its role in the burden of carotid atherosclerosis, measured by ultrasound as total plaque area. METHODS:Multiple regression with traditional risk factors was used to identify three ...

journal_title：Atherosclerosis

authors： Bogiatzi C,Gloor G,Allen-Vercoe E,Reid G,Wong RG,Urquhart BL,Dinculescu V,Ruetz KN,Velenosi TJ,Pignanelli M,Spence JD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Early detection of atrial fibrillation after stroke is important for secondary prevention in stroke patients without known atrial fibrillation (AF). We aimed to compare the performance of CHADS2, CHA2DS2-VASc and HATCH scores in predicting AF detected after stroke (AFDAS) and to test whether adding ...

journal_title：Atherosclerosis

authors： Hsieh CY,Lee CH,Wu DP,Sung SF

更新日期：2018-05-01 00:00:00

abstract：:Coronary heart disease (CHD) is one of the leading disorders with the highest mortality rate. Percutaneous angioplasty and stent implantation are the currently available standard methods for the treatment of obstructive coronary artery disease. However, the stent being an exogenous substance causes several complicatio...

journal_title：Atherosclerosis

authors： Liu S,Yang Y,Jiang S,Tang N,Tian J,Ponnusamy M,Tariq MA,Lian Z,Xin H,Yu T

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Peripheral artery disease (PAD) is associated with poor mobility and fatigue, but the relationship between preclinical ankle-brachial index (ABI) and early markers of fatigue and functional decline has not been defined. METHODS:570 adults, 50 and older, from the Baltimore Longitudinal Study of Agin...

journal_title：Atherosclerosis

authors： Martinez-Amezcua P,Matsushita K,Simonsick EM,Ferrucci L,Schrack JA

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker associated with cardiovascular disease. Statins lower both low-density lipoprotein (LDL)-cholesterol and C-reactive protein (CRP), resulting in improved outcomes. However, whether lipid-lowering therapy also lowers su...

journal_title：Atherosclerosis

authors： Hodges GW,Bang CN,Forman JL,Olsen MH,Boman K,Ray S,Kesäniemi YA,Eugen-Olsen J,Greve AM,Jeppesen JL,Wachtell K

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) may be associated with a wide spectrum of cardiac abnormalities, which share many metabolic risk factors. This study aimed to evaluate whether NAFLD is associated with left ventricular (LV) diastolic dysfunction independent of other classical risk factors. M...

journal_title：Atherosclerosis

authors： Chung GE,Lee JH,Lee H,Kim MK,Yim JY,Choi SY,Kim YJ,Yoon JH,Kim D

更新日期：2018-05-01 00:00:00

abstract：:The lifetime cardiovascular risk of a diabetic patient is approximately 4-5 times higher than that of an age and sex matched individual without diabetes mellitus. Despite the well-publicized cardiovascular risk equivalence of diabetes mellitus, it has become apparent that not all diabetic patients are equally at high-...

journal_title：Atherosclerosis

authors： Raggi P

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Whether carotid atherosclerosis is associated with an increased risk for ischemic stroke in patients with atrial fibrillation (AF) on anticoagulant treatment is undefined. To explore this association, patients with AF on treatment with vitamin K antagonists were included in a multicenter, prospectiv...

journal_title：Atherosclerosis

authors： Becattini C,Dentali F,Camporese G,Sembolini A,Rancan E,Tonello C,Manina G,Padayattil S,Agnelli G

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Abdominal aortic aneurysms (AAA) is a chronic inflammatory disease in which signal transducer and activator of transcription 3 (STAT3), and disintegrin and metalloproteinase 17 (ADAM17) play important roles. However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid ca...

journal_title：Atherosclerosis

authors： Zhai M,Guo J,Ma H,Shi W,Jou D,Yan D,Liu T,Tao J,Duan J,Wang Y,Li S,Lv J,Li C,Lin J,Zhang C,Lin L

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND AIMS:This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS:Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and t...

journal_title：Atherosclerosis

authors： Kim EN,Kim MY,Lim JH,Kim Y,Shin SJ,Park CW,Kim YS,Chang YS,Yoon HE,Choi BS

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Chronic intermittent hypoxia (CIH) exposure causes atherosclerosis, although the underlying mechanisms are poorly understood. This study defines the role of endothelial intrinsic NF-κB signaling in the atherogenic response to CIH. METHODS:We created ApoE-ECI-κBmt mice that are deficient in the apol...

journal_title：Atherosclerosis

authors： Song D,Fang G,Mao SZ,Ye X,Liu G,Miller EJ,Greenberg H,Liu SF

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The association between cholesterol and stroke has been inconsistent. This study aimed to examine the association between total cholesterol (TC) and mortality from total stroke and stroke subtypes. METHODS:503,340 Korean adults aged 40-80 years without a history of heart disease or stroke participa...

journal_title：Atherosclerosis

authors： Yi SW,Shin DH,Kim H,Yi JJ,Ohrr H

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduc...

journal_title：Atherosclerosis

authors： Pereira SC,Parente JM,Belo VA,Mendes AS,Gonzaga NA,do Vale GT,Ceron CS,Tanus-Santos JE,Tirapelli CR,Castro MM

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND AIMS:This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular...

journal_title：Atherosclerosis

authors： Yamamoto H,Yoshida N,Shinke T,Otake H,Kuroda M,Sakaguchi K,Hirota Y,Toba T,Takahashi H,Terashita D,Uzu K,Tahara N,Shinkura Y,Kuroda K,Nagasawa Y,Nagano Y,Tsukiyama Y,Yanaka KI,Emoto T,Sasaki N,Yamashita T,Ogawa

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND AIMS:An environment-wide association study (EWAS) may be useful to comprehensively test and validate associations between environmental factors and peripheral arterial disease (PAD) in an unbiased manner. METHODS:Data from cross-sectional cohorts from the US National Health and Nutrition Examination Sur...

journal_title：Atherosclerosis

authors： Zhuang X,Ni A,Liao L,Guo Y,Dai W,Jiang Y,Zhou H,Hu X,Du Z,Wang X,Liao X

更新日期：2018-02-01 00:00:00

abstract：:Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also kn...

journal_title：Atherosclerosis

authors： Martínez GJ,Celermajer DS,Patel S

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in ...

journal_title：Atherosclerosis

authors： Maruhashi T,Soga J,Fujimura N,Idei N,Mikami S,Iwamoto Y,Iwamoto A,Kajikawa M,Matsumoto T,Oda N,Kishimoto S,Matsui S,Hashimoto H,Aibara Y,Yusoff FM,Hidaka T,Kihara Y,Chayama K,Noma K,Nakashima A,Goto C,Tomiyama H

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Results from prospective studies evaluating the relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and incident peripheral arterial disease (PAD) have been mixed. We investigated whether higher Lp-PLA2 levels are associated with increased risk of incident PAD an...

journal_title：Atherosclerosis

authors： Garg PK,Norby FL,Polfus LM,Boerwinkle E,Gibbs RA,Grove ML,Folsom AR,Garimella PS,Matsushita K,Hoogeveen RC,Ballantyne CM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Generally, immoderate alcohol consumption is associated with variant angina and accepted as one of the risk factors for coronary artery spasm (CAS), but evidence is lacking in this regard. The aim of this study is to evaluate the impact of alcohol consumption and drinking pattern on CAS by acetylcho...

journal_title：Atherosclerosis

authors： Sohn SM,Choi BG,Choi SY,Byun JK,Mashaly A,Park Y,Jang WY,Kim W,Choi JY,Park EJ,Na JO,Choi CU,Lim HE,Kim EJ,Park CG,Seo HS,Oh DJ,Rha SW

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (SFE), and its potential anti-inflammatory mechanisms, in apoE knockout (ApoE-/-) mice. METHODS:Fifty male, ApoE-/- mice, fed a high-fat diet (HFD) for 12 weeks, were randomized into 5 groups: (1) baseline group, eut...

journal_title：Atherosclerosis

authors： Christodoulou E,Kadoglou NPE,Stasinopoulou M,Konstandi OA,Kenoutis C,Kakazanis ZI,Rizakou A,Kostomitsopoulos N,Valsami G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Statin is not beneficial for dialysis patients but moderate to high intensity statin is beneficial for patients after acute myocardial infarction (MI). The aim of this study was to evaluate the effect of moderate to high intensity statin on mortality, cardiovascular outcomes in dialysis patients aft...

journal_title：Atherosclerosis

authors： Chung CM,Lin MS,Chang CH,Cheng HW,Chang ST,Wang PC,Chang HY,Lin YS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS:To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. th...

journal_title：Atherosclerosis

authors： Vilne B,Skogsberg J,Foroughi Asl H,Talukdar HA,Kessler T,Björkegren JLM,Schunkert H

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The mechanisms that drive atherosclerotic plaque progression and destabilization in humans remain largely unknown. Laboratory models are needed to study these mechanisms under controlled conditions. The aim of this study was to establish a new ex vivo model of human atherosclerotic plaques that pres...

journal_title：Atherosclerosis

authors： Lebedeva A,Vorobyeva D,Vagida M,Ivanova O,Felker E,Fitzgerald W,Danilova N,Gontarenko V,Shpektor A,Vasilieva E,Margolis L

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Genetic and environmental factors are important components of the development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as regulators of multiple pathophysiological pathways in the cardiovascular system. Here, we investigated potential associations between lncRNAs and atheroscle...

journal_title：Atherosclerosis

authors： Arslan S,Berkan Ö,Lalem T,Özbilüm N,Göksel S,Korkmaz Ö,Çetin N,Devaux Y,Cardiolinc™ network.

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Low-density lipoprotein (LDL) apheresis has been used to treat refractory hyperlipidemia such as familial hypercholesterolemia (FH). Evolocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor used in clinical settings, can reduce LDL cholesterol (LDL-C) levels by >70%. Therefore, ...

journal_title：Atherosclerosis

authors： Kawashiri MA,Nohara A,Higashikata T,Tada H,Nakanishi C,Okada H,Konno T,Sakata K,Hayashi K,Inazu A,Mabuchi H,Yamagishi M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Childhood/Adult-onset Lysosomal Acid Lipase Deficiency (LAL-D) is a recessive disorder due to loss of function variants of LAL, the enzyme which hydrolyses cholesteryl esters, derived from internalized apoB containing lipoproteins. The disease is characterized by multi-organ involvement including th...

journal_title：Atherosclerosis

authors： Pisciotta L,Tozzi G,Travaglini L,Taurisano R,Lucchi T,Indolfi G,Papadia F,Di Rocco M,D'Antiga L,Crock P,Vora K,Nightingale S,Michelakakis H,Garoufi A,Lykopoulou L,Bertolini S,Calandra S

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Aortic atherosclerosis is an aggregate marker of vascular risk factor exposure and has been associated with intracranial atherosclerosis and stroke. We hypothesized that atherosclerosis of the descending aorta (DAo) could be a risk marker for brain aging and injury. METHODS:We evaluated 1527 partic...

journal_title：Atherosclerosis

authors： Aparicio HJ,Petrea RE,Massaro JM,Manning WJ,Oyama-Manabe N,Beiser AS,Kase CS,D'Agostino RB,Wolf PA,Vasan RS,DeCarli C,O'Donnell CJ,Seshadri S

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed at developing a novel risk prediction model for death from cardiovascular disease (CVD) for Chinese individuals, based upon a large cohort from Taiwan. METHODS:This Chinese cohort came from Taiwan, with 381,963 individuals free from CVD, recruited from a private health surveillance program...

journal_title：Atherosclerosis

authors： Hu WS,Lee JH,Tsai MK,Wen CP

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Oxidative modification of lipoproteins is a crucial step in atherosclerosis development. Isotopic-reinforced polyunsaturated fatty acids (D-PUFAs) are more resistant to reactive oxygen species-initiated chain reaction of lipid peroxidation than regular hydrogenated (H-)PUFAs. We aimed at investigati...

journal_title：Atherosclerosis

authors： Berbée JFP,Mol IM,Milne GL,Pollock E,Hoeke G,Lütjohann D,Monaco C,Rensen PCN,van der Ploeg LHT,Shchepinov MS

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b+Gr-1+ myeloid cells that play a critical role in infection, inflammation and tumorigenesis. The aim of this study was to explore the role of Hdc-expressing CD11b+ myeloid cells or histamine in atherogen...

journal_title：Atherosclerosis

authors： Xu L,Cheng D,Huang Z,Ding S,Zhang W,Tan H,Shi H,Chen R,Zou Y,Wang TC,Yang X,Ge J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Overt atherosclerotic cardiovascular disease (ASCVD) warrants aggressive lipid lowering. Imaging for ambiguous symptoms suggesting ischemia or for clarification of CV risk in asymptomatic individuals often uncovers previously unknown ASCVD. Guidelines do not provide clear recommendations for aggress...

journal_title：Atherosclerosis

authors： Mancini GBJ,Gupta M,Tsigoulis M,Cannon CP,Genest J,Ray KK,Santos RD,Watts GF,Raggi P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical diagnosis of FH do not have a detectable mutation in the genes ca...

journal_title：Atherosclerosis

authors： Sharifi M,Higginson E,Bos S,Gallivan A,Harvey D,Li KW,Abeysekera A,Haddon A,Ashby H,Shipman KE,Cooper JA,Futema M,Roeters van Lennep JE,Sijbrands EJG,Labib M,Nair D,Humphries SE

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm. METHODS:The Japan Collaborative Cohort (JACC) Study is a prospective comm...

journal_title：Atherosclerosis

authors： Kihara T,Yamagishi K,Iso H,Tamakoshi A,JACC Study Group.

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Individuals with type 1 diabetes mellitus are at high risk of developing atherosclerotic cardiovascular disease, but the underlying mechanisms by which type 1 diabetes accelerates atherosclerosis remain unknown. Increased retention of low-density lipoprotein (LDL) in atherosclerosis-prone sites of t...

journal_title：Atherosclerosis

authors： Hagensen MK,Mortensen MB,Kjolby M,Stillits NL,Steffensen LB,Bentzon JF

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time. METHODS:We analyzed a prospective longitudinal cohort of middl...

journal_title：Atherosclerosis

authors： Acosta S,Taimour S,Gottsäter A,Persson M,Engström G,Melander O,Zarrouk M,Nilsson PM,Smith JG

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The pathological process of atherosclerosis is closely related to lipid accumulation at arterial wall caused by lipoproteins transporting lipids through blood. In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE-/-) mice fed a high-fat diet to reveal...

journal_title：Atherosclerosis

authors： Chen Y,Wen S,Jiang M,Zhu Y,Ding L,Shi H,Dong P,Yang J,Yang Y

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The optimal approaches to management of patients treated with moderate statin doses on lipid parameters are unknown. The ACCENTUATE study aimed to compare the effects of adding the cholesteryl ester transfer protein inhibitor (CETP) evacetrapib, ezetimibe or increasing statin dose in atorvastatin-tr...

journal_title：Atherosclerosis

authors： Nicholls SJ,Ray KK,Ballantyne CM,Beacham LA,Miller DL,Ruotolo G,Nissen SE,Riesmeyer JS,ACCENTUATE Investigators.

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether bloo...

journal_title：Atherosclerosis

authors： Fagerberg B,Borné Y,Sallsten G,Smith JG,Acosta S,Persson M,Melander O,Forsgard N,Gottsäter A,Hedblad B,Barregard L,Engström G

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) has been associated with inflammation and cancer, however, its role in coronary artery disease (CAD) and cardiovascular outcome remains unclear. METHODS:Gal-3BP plasma levels were measured by ELISA in 2922 individuals from the LURIC study (62.7 ± 10.6 years, 62....

journal_title：Atherosclerosis

authors： Gleissner CA,Erbel C,Linden F,Domschke G,Akhavanpoor M,Helmes CM,Doesch AO,Kleber ME,Katus HA,Maerz W

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Bone marrow (BM)-derived progenitor cells are functionally impaired in patients with ischemic heart disease (IHD), thereby hampering the outcome of autologous stem cell therapy. In search for underlying mechanisms for this BM dysfunction, accelerated cellular senescence was explored. METHODS:We ana...

journal_title：Atherosclerosis

authors： Nollet E,Hoymans VY,Rodrigus IR,De Bock D,Dom M,Van Hoof VOM,Vrints CJ,Van Craenenbroeck EM

更新日期：2017-05-01 00:00:00